Introduction and Objective: Most adults with type 1 diabetes (T1DM) have overweight or obesity, underscoring the need for effective dietary weight loss strategies in this population. Time-restricted eating (TRE) has emerged as a popular approach; however, its efficacy and safety for weight management in adults with T1DM have not yet been evaluated. We examined whether TRE is more effective for reducing body weight than standard care (daily calorie restriction (CR)), or controls, in adults with T1DM and overweight or obesity. Methods: In this 6-month randomized controlled trial, adults aged 18-80 years with type 1 diabetes and BMI 25-50 kg/m² were randomized to one of three groups: TRE (eating only between 12-8 pm, without calorie counting), versus CR (25% energy restriction daily), and a no-intervention control group. The primary outcome was change in body weight by month 6 between groups. Analyses followed an intention-to-treat approach using linear mixed models. Results: Thirty-two participants were enrolled (mean SD body mass index 33 7 kg/m2; age 41 15 years; 59% female; HbA1c 7.3% 1.0%). By month 6, body weight did not change significantly in the TRE group (-2.19% 95% CI, -5.70, -1.31) or CR group (-0.47% 95% CI, -4.72, 3.78), relative to controls, or between TRE and CR groups (-1.73% 95% CI, -5.37, 1.92). HbA1c levels were significantly reduced by the TRE group when compared to the CR group (-0.46% 95% CI, -0.80, -0.12, P = 0.01). Insulin requirements, time in euglycemic range, and mean glucose levels remained unchanged. TRE did not increase the risk of diabetic ketoacidosis, severe hypoglycemia or hyperglycemia. Conclusion: These findings suggest that TRE may be a safe diet approach to improve HbA1c concentrations in T1DM, though not effective for weight loss when compared to CR or controls. Disclosure M. Runchey: None. S. Corapi: None. V. Pavlou: None. K. Varady: None.
Runchey et al. (Fri,) studied this question.
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