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Intramolecular dehydrogenative cyclization of aliphatic amides was achieved on unactivated sp(3) carbon atoms by a nickel-catalyzed CH bond functionalization process with the assistance of a bidentate directing group. The reaction favors the CH bonds of β-methyl groups over the γ-methyl or β-methylene groups. Additionally, a predominant preference for the β-methyl CH bonds over the aromatic sp(2) CH bonds was observed. Moreover, this process also allows for the effective functionalization of benzylic secondary sp(3) CH bonds.
Wu et al. (Wed,) studied this question.
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