A method that delivers medications in the systemic circulation and avoids the pre-systemic metabolism, such as intranasal, buccal, transdermal, and pulmonary routes, came into awareness to address these issues. This review deals with literature inclusion from the PubMed, Scopus, Web of Science and other reputed platforms. This article focuses on the merits, demerits, muco-cohesion mechanisms of buccal delivery system. A muco-adhesion is described as an interfacial adhesion in which a force of attraction holds one artificial mucoadhesive polymer and the opposing mucin layer (mucosal tissue) together. It has numerous advantages over other routes of administration with few drawbacks. In novel drug delivery system, mucoadhesive films/patches were developed to boost bioavailability and lower systemic toxicity. In conclusion, by increasing intrinsic or efficacy activity, it helps the target therapy. It has shown how mucoadhesive substances with quick and systemic potential work. Therefore, this strategy has become essential in the case of emergency treatment. Keywords: Buccal drug delivery system, NDDS, merits, limitations.
Yadav et al. (Sun,) studied this question.