The Syn-D Study: Detection of Longitudinal Changes in Cutaneous Phosphorylated Alpha-Synuclein in Mild Cognitive Impairment (S42.010)

Key Points

• To quantify the deposition of cutaneous phosphorylated alpha-synuclein in patients with mild cognitive impairment related to Alzheimer's disease and dementia with Lewy bodies.
• Investigation of phosphorylated alpha-synuclein in skin samples from participants with mild cognitive impairment.
• Comparison of results between patients diagnosed with Alzheimer's disease and those with dementia with Lewy bodies.
• Identified significant levels of phosphorylated alpha-synuclein in patients with mild cognitive impairment.
• Demonstrated a correlation between the cutaneous deposition and clinical markers of Alzheimer's and Lewy body dementia.