Chlamydia trachomatis is an obligate intracellular sexually transmitted human pathogen and a major cause of ocular and urogenital infections worldwide, causing significant reproductive and neonatal complications. Despite eliciting host immune responses, C. trachomatis infections frequently remain asymptomatic, contributing to silent epidemic that often progress to chronic disease. This paradox reflects the remarkable ability of the pathogen to intricately manipulate host cell survival pathways and immune signalling networks. This review synthesizes current knowledge of C. trachomatis pathogenesis and host–pathogen interactions, with a particular emphasis on immune evasion strategies, the implications of which might be effective for therapeutic and preventive approaches. Here we review how Chlamydia trachomatis rewires host cellular pathways to evade immune responses, sustaining a silent epidemic and provide key insights into host–pathogen interactions
Geetha et al. (Thu,) studied this question.