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July 3, 2019Science Advances417 citationsOpen Access

Single-base mapping of m 6 A by an antibody-independent method

ZZZhang Zhang LCLiqian Chen YZYuli Zhao

Key Points

This research aims to develop a new method for mapping m6A modifications at a single-base level in the transcriptome.
Introduced a novel antibody-independent technique for m6A mapping.
Conducted a transcriptome-wide analysis to assess m6A site conservation.
Generated reliable m6A maps demonstrating high precision at a single-base resolution.
Revealed conserved m6A site patterns across different mammalian species.

Abstract

A new transcriptome-wide method produces reliable m 6 A maps at single-base resolution and reveals site conservation in mammals.

Demander à l'IA

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Demander à l'IA

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Cite This Study

Zhang et al. (2019) studied this question.

synapsesocial.com/papers/6a2edc4866e347ad8cd657ea https://doi.org/https://doi.org/10.1126/sciadv.aax0250

Cartographie à base unique de l' m 6 A par une méthode indépendante d'anticorps | Synapse