Brachial-ankle pulse wave velocity in the top decile was associated with a higher risk of all-cause mortality compared to the whole study population (HR 1.56; 95% CI 1.16-2.08; P≤0.003).
Cohort (n=3,876)
No
Does high brachial-ankle pulse wave velocity predict mortality in an elderly Chinese population?
Markedly increased brachial-ankle pulse wave velocity is a significant predictor of all-cause mortality in elderly Chinese individuals, particularly those with hypertension.
Hazard Ratio: 1.56 (95% CI 1.16–2.08)
p-value: p=≤0.003
Pulse wave velocity (PWV) is a measure of arterial stiffness and predicts cardiovascular events and mortality in the general population and various patient populations. In the present study, we investigated the predictive value of brachial-ankle PWV for mortality in an elderly Chinese population. Our study subjects were older (≥60 years) persons living in a suburban town of Shanghai. We measured brachial-ankle PWV using an automated cuff device at baseline and collected vital information till June 30, 2013, during follow-up. The 3876 participants (1713 44.2% men; mean ±SD age, 68.1±7.3 years) included 2292 (59.1%) hypertensive patients. PWV was on average 17.8 (±4.0) m/s and was significantly (P<0.0001) associated with age (r=0.48) and in unadjusted analysis with all-cause (n=316), cardiovascular (n=148), stroke (n=46), and noncardiovascular mortality (n=168) during a median follow-up of 5.9 years. In further adjusted analysis, we studied the risk of mortality according to the decile distributions of PWV. Only the subjects in the top decile (23.3-39.3 m/s) had a significantly (P≤0.003) higher risk of all-cause mortality (hazard ratio relative to the whole study population, 1.56; 95% confidence interval, 1.16-2.08), especially in hypertensive patients (hazard ratio, 1.86; 95% confidence interval, 1.31-2.64; P=0.02 for the interaction between PWV and hypertension). Similar trends were observed for cardiovascular, stroke, and noncardiovascular mortality, although statistical significance was not reached (P≥0.08). In conclusion, brachial-ankle PWV predicts mortality in elderly Chinese on the conditions of markedly increased PWV and hypertension.
Sheng et al. (Tue,) conducted a cohort in Elderly population (n=3,876). Brachial-ankle pulse wave velocity (top decile: 23.3-39.3 m/s) vs. Whole study population was evaluated on All-cause mortality (HR 1.56, 95% CI 1.16-2.08, p=≤0.003). Brachial-ankle pulse wave velocity in the top decile was associated with a higher risk of all-cause mortality compared to the whole study population (HR 1.56; 95% CI 1.16-2.08; P≤0.003).
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