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TDP-43 protein is the major component of the ubiquitin-positive inclusions in neurons and glia of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP).11 TDP-43 pathology has also been detected in as many as 56% of patients with Alzheimer disease (AD
Rutherford et al. (Thu,) studied this question.
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