Background/Objectives: Denture disinfection is a crucial step in reducing microbial colonization and the risk of denture stomatitis, as well as contributing to patient health and denture longevity; thus, it was obligatory to select an effective cleanser without undesirable impact on properties of acrylic denture base material. This study aimed to assess the synergistic effect of white vinegar and sodium bicarbonate (WVSB) mixture on Candida albicans by means of colony forming unit (CFU) and adhesion assays, as well as the surface roughness and flexural strength of heat-cured acrylic denture base material after being immersed in the WVSB mixture. Methods: In total, 200 specimens of heat-cured acrylic resin were prepared: 50 per each test, 5 per each group. They were divided into ten groups; distilled water (negative control), a Corega denture cleanser tablet soaked for 5 min (positive control), and four concentrations (2%, 3%, 4% and 5%) of WVSB mixture were made and examined for (5 and 10 min) immersion durations. Statistical analysis was performed by using Welch’s ANOVA alongside Games–Howell post hoc tests for CFU assay and one-way ANOVA along with Tukey HSD post hoc tests for remaining tests. A p < 0.05 was considered significant in all experiments. Results: The results for the CFU, adhesion and surface roughness tests showed that the WVSB mixture demonstrated a statistically significant difference in most test groups compared to the negative control group, while the flexural strength test showed a statistically non-significant difference. Conclusions: The WVSB mixture showed concentration and time-dependent antifungal effects against C. albicans, with increased surface roughness and no negative effect on the flexural strength of heat-cure acrylic.
Mohsin et al. (Mon,) studied this question.