MINOCA occurs in 5-15% of patients presenting with acute myocardial infarction, highlighting the need for intravascular imaging and coronary function testing for accurate diagnosis.
This review highlights the diagnostic pathway and management strategies for MINOCA, emphasizing the need for targeted, evidence-based therapies.
MI with non-obstructive coronary arteries (MINOCA) is caused by a heterogeneous group of vascular or myocardial disorders. MINOCA occurs in 5.15% of patients presenting with acute ST-segment elevation MI or non-ST segment elevation MI and prognosis is impaired. The diagnosis of MINOCA is made during coronary angiography following acute MI, where there is no stenosis ≥50% present in an infarct-related epicardial artery and no overt systemic aetiology for the presentation. Accurate diagnosis and subsequent management require the appropriate utilisation of intravascular imaging, coronary function testing and subsequent imaging to assess for myocardial disorders without coronary involvement. Although plaque-related MINOCA is currently managed with empirical secondary prevention strategies, there remains an unmet therapeutic need for targeted and evidence-based therapy for MINOCA patients and increased awareness of the recommended diagnostic pathway.
Sykes et al. (Thu,) conducted a review in MI with non-obstructive coronary arteries (MINOCA). MINOCA occurs in 5-15% of patients presenting with acute myocardial infarction, highlighting the need for intravascular imaging and coronary function testing for accurate diagnosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: