Lactoferrin administration remarkably alleviated cardiac fibrosis and remodeling, improved cardiac function, and reduced the incidence of heart failure in mice post-myocardial infarction by inhibiting the mTORC1/S6K/eIF-4B signaling pathway.
Does lactoferrin attenuate cardiac fibrosis and improve cardiac function after myocardial infarction in mice?
Lactoferrin attenuates adverse cardiac remodeling and fibrosis after myocardial infarction by inhibiting the mTORC1/S6K/eIF-4B signaling pathway, highlighting its potential as a novel therapeutic target.
Our study established the cardiac protective role of Ltf in attenuating cardiac remodeling and improving cardiac function by inhibiting the activation of myofibroblasts through suppressing mTORC1/S6K/eIF-4B signaling pathway post-MI. Treatment with Ltf may serve as a potential novel therapeutic intervention in patients with MI.
Ye et al. (Sun,) conducted a other in Myocardial infarction. Lactoferrin vs. Vehicle/Control was evaluated on Cardiac fibrosis and cardiac function. Lactoferrin administration remarkably alleviated cardiac fibrosis and remodeling, improved cardiac function, and reduced the incidence of heart failure in mice post-myocardial infarction by inhibiting the mTORC1/S6K/eIF-4B signaling pathway.
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