Overweight and obesity in STEMI patients undergoing initial PCI were associated with lower in-hospital mortality compared to healthy weight (OR 0.66, 95% CI 0.58-0.76 and OR 0.60, 95% CI 0.51-0.72).
Meta-Analysis
Does overweight or obese BMI status reduce mortality in STEMI patients after initial PCI compared to healthy-weight status?
This meta-analysis confirms the existence of an obesity paradox in STEMI patients undergoing PCI, where overweight and obese patients have lower mortality across multiple time horizons compared to healthy-weight patients.
Odds Ratio: 0.66 (95% CI 0.58–0.76)
p-value: p=<0.001
OBJECTIVE: The aim of this study was to investigate whether there was a difference in survival after initial percutaneous coronary intervention (PCI) among ST-segment elevation myocardial infarction (STEMI) patients with different body mass index (BMI). METHODS: Literature retrieval was conducted on PubMed, Web of Science, Embase, CNKI, and Wanfang databases to obtain the published studies on the survival of STEMI patients with different BMI after initial PCI from the establishment of the database to 2022. All statistical analyses were performed using STATA16.0. RESULTS: Two hundred thirty-nine studies were retrieved, and 12 studies were eventually included. Meta-analysis showed that overweight patients OR = 0.66, 95% CI (0.58, 0.76), p .05, short-term mortality OR = 1.04, 95% CI (0.89, 1.22), p > .05, and long-term mortality OR = 1.07, 95% CI (0.95, 1.20), p > .05 between overweight and obese patients. CONCLUSION: This meta-analysis confirmed an obesity paradox in STEMI patients following PCI. The obesity paradox exists in in-hospital, short-term, and long-term conditions.
Liu et al. (Mon,) conducted a meta-analysis in ST-segment elevation myocardial infarction (STEMI). Overweight and obesity vs. Healthy-weight patients was evaluated on In-hospital mortality (OR 0.66, 95% CI 0.58-0.76, p=<0.001). Overweight and obesity in STEMI patients undergoing initial PCI were associated with lower in-hospital mortality compared to healthy weight (OR 0.66, 95% CI 0.58-0.76 and OR 0.60, 95% CI 0.51-0.72).