The article proposes a physical rethinking of carcinogenesis based on the Non-Information Theory of Life (NJT), the theory of meta-environments and the concept of phase topology of water. It has been shown that cancer is not only a genetic disease, but also a fundamental violation of supramolecular dynamics, degradation of the tetrahedral network of water (shift of LDL/HDL equilibrium, destruction of tetrasignures), destabilization of condensates and pathology of the body's meta-environments. The Warburg effect (transition to glycolysis) changes the physical parameters of the cell – pH, ionic composition, temperature, redox potential, which shifts the equilibrium towards chaotic HDL water, destroys tetrasignatures, disrupts liquid phase separation and destabilizes the chromatin hydrate shell. At the same time, meta-environments are damaged: glycocalyx thins, extracellular matrix degrades, blood rheology and interstitial transport change. Loss of ensemble coherence and destruction of tetrassignatures lead to chaotic transcription, dedifferentiation, uncontrolled division and metastasis, which is enhanced by electrotaxis – directed migration of cells in abnormal electric fields of the tumor. All major types of cancer are considered: solid tumors (carcinomas, sarcomas), hematologic tumors (leukemias, lymphomas), neuroendocrine, and germ cell tumors. It is shown that regardless of tissue origin, they are all united by a common physical mechanism, such as the loss of coherence of the supramolecular network, the destruction of tetrasignatures, and damage to meta-media. Operational methods for testing the theory are proposed: NMR relaxometry to assess the structure of nucleomorphic water (T1/T2), transcriptomic analysis to assess transcription randomness, fluorescence microscopy to visualize condensates, mass spectrometry to analyze the ion composition of the nucleus, as well as assessment of the state of glycocalyx and extracellular matrix. A clinical case of the use of the Quatotron technique in a 57-year-old patient with inoperable grade IV glioblastoma is presented, demonstrating tumor growth arrest and restoration of cognitive functions. The main conclusion: Cancer is a disease of supramolecular dynamics, phase topology of water and metamedia, and not only genes. Mutations are secondary events. Restoration of the coherence of ensembles, tetrasignatures, hydrate membrane and functional integrity of meta-media should suppress the cancer phenotype without changing the genome.
Vladimir Lagoda (Mon,) studied this question.