Sub-optimal 3D echocardiography image quality introduces a substantial systematic bias, underestimating strain indices by approximately 10% and twist/torsion by approximately 20% compared to optimal images.
Cross-Sectional (n=36)
Single-blind
No
Does sub-optimal image quality cause bias in 3D-STE derived left ventricular indices in healthy participants?
Sub-optimal image quality in 3D-STE introduces substantial systematic underestimation bias in LV mechanics, which may confound clinical assessments and associations between disease and LV mechanics.
BACKGROUND: Three-dimensional speckle-tracking echocardiography (3D-STE) is increasingly used to assess left ventricular (LV) mechanics but the quantitative effect of image quality on measurements is not known. OBJECTIVES: To assess the impact of image quality on 3D-STE derived LV indices. METHODS: Echocardiography was performed in two groups of 18 healthy participants. In the first study, optimal and intentionally poor-quality images were acquired. In the second study, a sheet of ultrasound-attenuating material (neoprene rubber) of three different thicknesses (2, 3 and 4 mm) was used to mimic mildly, moderately and severely impaired image quality respectively. RESULTS: In both studies sub-optimal image quality resulted in a systematic underestimation bias in all LV deformation and rotational indices. LV ejection fraction and volumes were also consistently underestimated. The extent of the bias was proportional to the impairment in image quality (i.e. the poorer the image quality the larger the bias). Reproducibility was also less good for sub-optimal images, although LV volumes and ejection fraction showed excellent reproducibility irrespective of image quality. CONCLUSIONS: Sub-optimal image quality introduces a substantial systematic bias and impairs the reproducibility of 3D-STE. Bias related to image quality might have important clinical implications since its magnitude is similar to that reported in association with disease and may confound associations between disease and LV mechanics.
Saikhan et al. (Tue,) conducted a cross-sectional in Healthy (n=36). Sub-optimal image quality vs. Optimal image quality was evaluated on Systematic bias in left ventricular deformation and rotational indices. Sub-optimal 3D echocardiography image quality introduces a substantial systematic bias, underestimating strain indices by approximately 10% and twist/torsion by approximately 20% compared to optimal images.