August 29, 1991
View Full PaperSympathetic Stimulation and Arrhythmias
Key Result
Sympathetic stimulation was associated with an almost fivefold increase in cardiac norepinephrine spillover in patients with reduced left ventricular function and ventricular arrhythmias.
Structured PICO
Is sympathetic stimulation associated with increased cardiac norepinephrine spillover and ventricular arrhythmias in patients with reduced left ventricular function?
P
Population
Patients with reduced left ventricular function and ventricular arrhythmias (referenced study)
O
Outcome
Cardiac norepinephrine spilloversurrogate
This editorial highlights evidence that sympathetic stimulation is associated with a significant increase in cardiac norepinephrine spillover in patients with reduced left ventricular function and ventricular arrhythmias.
Main Result
Effect estimate: almost fivefold increase
Abstract
For many years it has been recognized that sympathetic nervous stimulation can influence the development of cardiac arrhythmias in both normal and abnormal hearts, during ischemic and nonischemic states, and that β-adrenergic—receptor blockade or surgical interruption of the stellate ganglia can prevent these arrhythmias. The mechanism by which the autonomic nervous system precipitates or prevents the arrhythmias is not known. In this issue of the Journal, Meredith et al.1 provide information about the association between sympathetic stimulation and ventricular arrhythmias, demonstrating an almost fivefold increase in cardiac norepinephrine spillover in patients with reduced left ventricular function who had had . . .
Cite This Study
Douglas P. Zipes (Thu,) conducted a editorial in Ventricular arrhythmias and reduced left ventricular function. Sympathetic stimulation was evaluated on Cardiac norepinephrine spillover (almost fivefold increase). Sympathetic stimulation was associated with an almost fivefold increase in cardiac norepinephrine spillover in patients with reduced left ventricular function and ventricular arrhythmias.