Dilated cardiomyopathy was associated with higher peak turbulent kinetic energy at late diastolic filling compared to healthy subjects (3.0 ± 1.8 vs. 1.5 ± 0.8 mJ, P=0.02).
Cross-Sectional (n=20)
Does turbulent kinetic energy measured by 4D flow MRI differ between healthy subjects and patients with dilated cardiomyopathy?
4D flow MRI demonstrates that late diastolic turbulent kinetic energy is elevated in patients with dilated cardiomyopathy compared to healthy subjects, correlating with LV diameter and transmitral velocity.
Absolute Event Rate: 3% vs 1.5%
p-value: p=0.02
PURPOSE: To assess turbulent kinetic energy (TKE) within the left ventricle (LV) of healthy subjects using novel 4D flow magnetic resonance imaging (MRI) methods and to compare TKE values to those from a limited group of patients with a spectrum of dilated cardiomyopathy (DCM). MATERIALS AND METHODS: 4D flow and morphological MRI data were acquired in 11 healthy subjects and 9 patients with different degrees of diastolic dysfunction. TKELV was calculated within the LV at each diastolic timeframe. At peak early (E) and late (A) diastolic filling, the TKELV was compared to transmitral peak velocity, LV diameter, and mitral annular diameter. RESULTS: In the majority of subjects, TKELV peaks were observed at E and A. Peak TKELV at E was not different between the groups (P = 0.33), and correlated with mitral annular dimensions (r(2) = 0.32, P = 0.01). Peak TKELV at A was higher in DCM patients compared to healthy subjects (3.0 ± 1.8 vs. 1.5 ± 0.8 mJ, P = 0.02), and correlated with LV diameter and transmitral velocity (r(2) = 0.36, P = 0.01 and r(2) = 0.47, P < 0.01, respectively). CONCLUSION: In LVs of healthy subjects, TKE values are low. Values are highest during early diastole, and diminish with increasing LV size. In a heterogeneous group of DCM patients, late diastolic TKE values are higher than in healthy subjects.
Zajac et al. (Tue,) conducted a cross-sectional in Dilated cardiomyopathy (n=20). Dilated cardiomyopathy vs. Healthy subjects was evaluated on Peak turbulent kinetic energy (TKELV) at late (A) diastolic filling (p=0.02). Dilated cardiomyopathy was associated with higher peak turbulent kinetic energy at late diastolic filling compared to healthy subjects (3.0 ± 1.8 vs. 1.5 ± 0.8 mJ, P=0.02).