April 18, 2023Open Access

Rational Design of Meso -Diaminopimelate Dehydrogenase with Enhanced Reductive Amination Activity for Efficient Production of d - p -Hydroxyphenylglycine

YTYang TanJiangnan University CGChangzheng GaoJiangnan University WSWei SongJiangnan University

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Abstract

d - p -hydroxyphenylglycine ( d -HPG) is an important intermediate in the synthesis of antimicrobial compounds. d -HPG is mainly produced via chemical and enzymatic approaches, and enzymatic asymmetric amination employing diaminopimelate dehydrogenase (DAPDH) is considered an attractive method.

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Tan et al. (Tue,) studied this question.

synapsesocial.com/papers/6a6234ee5aedc878c5f56f47 https://doi.org/https://doi.org/10.1128/aem.00109-23

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