In spontaneously hypertensive rats, progression of hypertension to 12 months of age increased expression of procollagen type III and collagen type V in the kidney, and collagen types I and V in the myocardium.
AIM: The aim of the present study was to investigate the immunohistochemical expression of selected collagen types, namely collagen types I and V and procollagen type III in the renal parenchyma and interstitium and in the myocardium of spontaneously hypertensive rats. MATERIAL AND METHODS: For the present study, we used two age groups of 6- and 12-month-old spontaneously hypertensive rats. An immunohistochemical analysis was conducted with monoclonal antibodies against collagen types I and V and procollagen type III. A semi-quantitative analysis of immunostaining intensity was conducted with the Image J software. RESULTS: In the kidney, all three molecules showed higher expression at the age of 12 months, which was particularly notable for procollagen type III and collagen type V, which stained as highly-positive. In the myocardium, the immunoreactivity of collagen types I and V was stronger in 12-month-old animals, while that of procollagen type III did not change substantially. CONCLUSION: The present study suggests a role of collagen types III and V in hypertensive kidney disease, while also establishing the role of increased expression of collagen types I and V in adverse myocardial remodeling (Tab. 1, Fig. 2, Ref. 48).
Stanchev et al. (Wed,) conducted a other in Hypertension (n=6). Hypertension progression (12 months of age) vs. 6 months of age was evaluated on Immunohistochemical expression of collagen types I and V and procollagen type III in the kidney and myocardium. In spontaneously hypertensive rats, progression of hypertension to 12 months of age increased expression of procollagen type III and collagen type V in the kidney, and collagen types I and V in the myocardium.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: