August 12, 2026Journal of the American College of Cardiology278 citationsOpen Access
The Growing Clinical Importance of Secondary Tricuspid Regurgitation
Key Result
A review of secondary tricuspid regurgitation highlights growing evidence favoring a more aggressive surgical approach and explores its pathophysiology and management.
Key Points
- The aim is to review the anatomical features, pathophysiology, and treatment strategies of secondary tricuspid regurgitation.
- Literature review covering surgical approaches to secondary tricuspid regurgitation
- Exploration of the anatomical and physiological factors influencing treatment outcomes
- Discussion of future directions in management
- Growing evidence supports more aggressive surgical approaches for secondary tricuspid regurgitation.
- Increased understanding of the anatomical and physiological underpinnings of the condition.
- Heightened awareness about the need to address secondary tricuspid regurgitation in clinical practice.
Structured PICO
P
Population
Patients with functional or secondary tricuspid regurgitation (STR)
I
Intervention
Management of secondary tricuspid regurgitation, including surgical tricuspid repair
This review emphasizes the increasing clinical importance of secondary tricuspid regurgitation and supports a more proactive surgical approach to its management.
Abstract
Functional or secondary tricuspid regurgitation (STR) is the most frequent etiology of tricuspid valve pathology in Western countries. Surgical tricuspid repair has been avoided for years, because of the misconception that tricuspid regurgitation should disappear once the primary left-sided problem is treated; this results in a large number of untreated patients with STR. Over the past few years, many investigators have reported evidence in favor of a more aggressive surgical approach to STR. Consequently, interest has been growing in the physiopathology and treatment of STR. The purpose of this review is to explore the anatomical basis, pathophysiology, therapeutic approach, and future perspectives with regard to the management of STR.