Enhanced: Antigen Presentation by Memory B Cells--The Sting Is in the Tail

Antibody molecules come in many forms. Some reside on the surfaces of immune cells, where they have a dual function. They transduce signals into the cell but also bind antigen so that it can be endocytosed and processed. In his Perspective, Tarlinton explains how three reports in this issue (Weiser et al., Kaisho et al., and Achatz et al.) and one in EMBO Journal shed new light on how these surface-localized molecules can perform both of these functions--the key is in the intracellular tail.