Amiodarone-lnduced Delirium

PSYCHIATRIC disturbances have not been associated with amiodarone therapy (1, 2). We report the case of a pa-tient who had an acute episode of delirium while taking amiodarone. The delirium was completely reversed after discontinuation of amiodarone therapy. A 66-year-old white man with no previous psychiatric history was referred for electrophysiologic testing. He had an 8-year history of recurrent wide QRS complex tachycardia unsuccess-fully treated with procainamide, quinidine, and tocainide. He had used alcohol heavily, but denied any alcohol use for 16 years. On admission, his antiarrhythmic therapy (mexiletine, 200 mg orally every 8 hours) was discontinued. He subsequently developed several episodes of sustained wide QRS complex tachycardia refractory to treatment with lidocaine and bretyli-