The Nature of Arterial Hypertension With Special Reference to the Rôle of the Kidney

Article1 April 1939THE NATURE OF ARTERIAL HYPERTENSION WITH SPECIAL REFERENCE TO THE RÔLE OF THE KIDNEYMYRON PRINZMETAL, BEN FRIEDMAN, DAVID I. ABRAMSON, F.A.C.P.MYRON PRINZMETALSearch for more papers by this author, BEN FRIEDMANSearch for more papers by this author, DAVID I. ABRAMSON, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-10-1604 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince cardiac output,1 blood volume,2 and blood viscosity3 are normal in patients with hypertension, the only remaining factor that might produce the elevated blood pressure is an increased peripheral resistance. This increased resistance is presumably generalized throughout the systemic circulation, and is the result of vascular hypertonus4 confined to the arterioles although the small arteries may also be involved.5The generalized arteriolar hypertonus responsible for hypertension could theoretically be produced by increased sympathetic vasomotor impulses or by circulating substances having a direct or indirect constrictor action on the arterioles.Hypertension may be produced experimentally by means of renal ischemia,7ureteral...Bibliography1. LANTERBAUMAN SH(a) : Ueber den Kreislauf bei Hochdruck Arteriosklerose und Apoplexie, Ztschr. f. klin. Med., 1928, cix, 415. (b) BURWELL, C. S., and SMITH, W. C.: The output of the heart in patients with abnormal blood pressures, Jr. Clin. Invest., 1929, vii, 1. (c) WEISS, S., and ELLIS, L. B.: The quantitative aspects and dynamics of the circulatory mechanism in arterial hypertension, Am. Heart Jr., 1930, v, 448. (d) GLADSTONE, S. 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BUTLER AM(a) : Chronic pyelonephritis and arterial hypertension, Jr. Clin. Invest., 1937, xvi, 889. (b) KERR, W. J.: Personal communication. (c) PRINZMETAL, M.: Unpublished observation. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 26, 1938.A preliminary report of this paper has appeared:PRINZMETAL, M., and FRIEDMAN, B.: Pressor effects of kidney extracts from patients and dogs with hypertension, Proc. Soc. Exper. Biol. and Med., 1936, xxxv, 122-124.†Work done during the tenure of Richard and Ella Hunt Sutro Fellowships.From the Medical Service of Dr. B. S. Oppenheimer and the Laboratory Division of The Mount Sinai Hospital, New York City.‡Hartwich20b ligated the renal artery and vein of one dog. The pressed juice of the necrotic kidney gave pressor effects but he was unable to determine whether or not this pressor effect was greater than that of the normal kidney of this animal or that of other kidneys of normal dogs. Hartwich did not measure the blood pressure of this animal but it is now known that ligation of the renal artery and vein is not followed by hypertension.18 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhysiologie und Pathologie des Renin/Angiotensin-SystemsRenin und Hypertensin, physiologische oder pathologische Wirkstoffe?Herz und KreislaufKlinikThe Nature of the Pressor and Depressor Factors Derived from the KidneyThe action of angiotonin on the completely isolated mammalian heart 1 April 1939Volume 12, Issue 10Page: 1604-1616KeywordsArteriolesBlood pressureHypertensionKidneysMedical servicesRabbitsRenal arteriesRenal ischemiaResearch laboratoriesVeins ePublished: 1 December 2008 Issue Published: 1 April 1939 PDF downloadLoading ...