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Obstruction and reestablishment of coronary artery flow both markedly lower the threshold for ventricular fibrillation (VF). This reduction in threshold is partially reversed by infusion of Prenylamine, a drug with slow channel blocking and coronary artery vasodilating properties. Mean blood pressure and heart rate were unaltered. Prenylamine administration also elevated the VF threshold in the nonischemic myocardium. Its effect on reperfusion VF threshold is unique, since commonly used antiarrhythmic drugs exert no such effect.
Schoeneberger et al. (1979) studied this question.