Why the study?
Does prenylamine infusion improve the ventricular fibrillation threshold in normal and ischemic canine myocardium?
Does prenylamine infusion improve the ventricular fibrillation threshold in normal and ischemic canine myocardium?
Prenylamine uniquely elevates the ventricular fibrillation threshold during ischemia and reperfusion in a canine model without affecting hemodynamics.
Does not support clinical use; hypothesis-generating for prenylamine in human VF prevention during ischemia/reperfusion.
Obstruction and reestablishment of coronary artery flow both markedly lower the threshold for ventricular fibrillation (VF). This reduction in threshold is partially reversed by infusion of Prenylamine, a drug with slow channel blocking and coronary artery vasodilating properties. Mean blood pressure and heart rate were unaltered. Prenylamine administration also elevated the VF threshold in the nonischemic myocardium. Its effect on reperfusion VF threshold is unique, since commonly used antiarrhythmic drugs exert no such effect.
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Schoeneberger et al. (1979) studied this question.
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