What question did this study set out to answer?

This research investigates how chronic amiodarone pretreatment influences ischemic ventricular arrhythmias in conscious dogs.

November 1, 1982Journal of Cardiovascular Pharmacology

Beneficial Effects of Amiodarone Pretreatment on Early Ischemic Ventricular Arrhythmias Relative to Infarct Size and Regional Myocardial Blood Flow in the Conscious Dog

View Full Paper

Ask AI

Bookmark

Why the study?

Does amiodarone pretreatment reduce early ischemic ventricular arrhythmias in conscious dogs with myocardial infarction?

Population

Fully conscious instrumented dogs with large myocardial infarcts (n=25)

Comparison

Amiodarone (30 mg/kg daily) for 3-4 weeks vs Control dogs (no amiodarone pretreatment)

Design

Preclinical

Follow-up

6 hours following coronary occlusion

Authors

CCChristopher ChewUniversity of North Carolina at Chapel Hill JCJ. T. ColletWadsworth Center CCClaudia CampbellWadsworth Center

Discussion

Member takes

Implication

Should not change post-MI arrhythmia management; leaves open translation of canine antiarrhythmic effects to humans.

Key Points

This research investigates how chronic amiodarone pretreatment influences ischemic ventricular arrhythmias in conscious dogs.
Evaluated 25 fully conscious instrumented dogs with myocardial infarcts.
Dogs received amiodarone (30 mg/kg daily) for 3-4 weeks and compared with control.
Analyzed effects on infarct size, regional blood flow, and arrhythmia frequency.
Amiodarone significantly reduced the incidence of ventricular fibrillation from 29% (control) to 9% (treated).
Lengthened epicardial conduction delay from 191 +/- 20 ms to 239 +/- 81 ms (p < 0.05).
Marked attenuation of early ventricular arrhythmias led to ectopy-free intervals of up to 6 hours.

Structured PICO

Does amiodarone pretreatment reduce early ischemic ventricular arrhythmias in conscious dogs with myocardial infarction?

Population

Fully conscious instrumented dogs with large myocardial infarcts (n=25)

Intervention

Amiodarone (30 mg/kg daily) for 3-4 weeks

Comparator

Control dogs (no amiodarone pretreatment)

Outcome

Frequency and severity of early ischemic ventricular arrhythmias and incidence of ventricular fibrillationsurrogate

Chronic amiodarone pretreatment reduces the frequency of early ventricular arrhythmias and the incidence of ventricular fibrillation following coronary occlusion in a canine model.

Cite This Study

Chew et al. (1982) studied this question.

synapsesocial.com/papers/6a73250e7c93a8454ca0bb34 https://doi.org/10.1097/00005344-198211000-00024

View Full Paper

Ask AI

Bookmark

Beneficial Effects of Amiodarone Pretreatment on Early Ischemic Ventricular Arrhythmias Relative to Infarct Size and Regional Myocardial Blood Flow in the Conscious Dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Beneficial Effects of Amiodarone Pretreatment on Early Ischemic Ventricular Arrhythmias Relative to Infarct Size and Regional Myocardial Blood Flow in the Conscious Dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider