Why the study?
Does short-term intravenous or long-term oral amiodarone prevent ventricular fibrillation in a conscious canine model of sudden coronary death?
Population
Conscious canine preparation of sudden coronary death, n=41.
Comparison
Short-term intravenous amiodarone or long-term… vs Control group (randomly assigned).
Design
Preclinical, Animals within each group were randomly assigned to control or…
Follow-up
Up to 24 days for long-term oral group
Authors
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Amiodarone shows promise in canine VF models but should not yet alter practice; leaves open translation to human sudden death prevention.
Does short-term intravenous or long-term oral amiodarone prevent ventricular fibrillation in a conscious canine model of sudden coronary death?
In a canine model of sudden coronary death, both short-term intravenous and long-term oral amiodarone significantly reduced the incidence of ventricular fibrillation, with long-term oral therapy demonstrating greater efficacy and more pronounced QT prolongation.
Patterson et al. (1983) studied this question.
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