What question did this study set out to answer?

This research aims to evaluate the acute electrophysiologic and antiarrhythmic effects of intravenous amiodarone in chronically infarcted cats.

September 1, 1989Journal of Cardiovascular Pharmacology

Acute Electrophysiologic Effects and Antiarrhythmic/Antifibrillatory Activity of Intravenous Amiodarone in a Chronic Feline Infarction Model

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Why the study?

Does intravenous amiodarone prevent inducible ventricular arrhythmias in a chronic feline infarction model?

Population

9 chronically infarcted cats

Comparison

Intravenous amiodarone vs Baseline (before drug administration)

Design

Preclinical

Follow-up

Acute

Authors

RMRoger A. MarinchakAbington Memorial Hospital KOKathleen M. OʼConnorUniversité de Lille TFTed D. FriehlingAdventist HealthCare

Discussion

Member takes

Implication

Questions acute IV amiodarone efficacy in chronic infarction models despite threshold rise; leaves open optimal regimens and species translation for arrhythmia research.

Key Points

This research aims to evaluate the acute electrophysiologic and antiarrhythmic effects of intravenous amiodarone in chronically infarcted cats.
Evaluated effects of amiodarone in nine chronically infarcted cats
Measured changes in heart rate, ventricular effective refractory period, and fibrillation threshold
Assessed arrhythmia inducibility before and after amiodarone administration.
Mean heart rate decreased by 17% after amiodarone administration.
Mean ventricular effective refractory period increased by 10%.
No significant reduction in malignant ventricular arrhythmias; 63% of cats remained inducible post-treatment.

Structured PICO

Does intravenous amiodarone prevent inducible ventricular arrhythmias in a chronic feline infarction model?

Population

9 chronically infarcted cats

Intervention

Intravenous amiodarone

Comparator

Baseline (before drug administration)

Outcome

Electrophysiologic parameters (heart rate, ventricular effective refractory period, ventricular fibrillation threshold) and incidence of malignant ventricular arrhythmias induced by programmed stimulationsurrogate

In a chronic feline infarction model, acute intravenous amiodarone alters electrophysiologic parameters but does not significantly reduce the incidence of inducible malignant ventricular arrhythmias.

Cite This Study

Marinchak et al. (1989) studied this question.

synapsesocial.com/papers/6a71b61bfebe604dd70a3e95 https://doi.org/10.1097/00005344-198909000-00006

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Implication

Questions acute IV amiodarone efficacy in chronic infarction models despite threshold rise; leaves open optimal regimens and species translation for arrhythmia research.

Acute Electrophysiologic Effects and Antiarrhythmic/Antifibrillatory Activity of Intravenous Amiodarone in a Chronic Feline Infarction Model

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Acute Electrophysiologic Effects and Antiarrhythmic/Antifibrillatory Activity of Intravenous Amiodarone in a Chronic Feline Infarction Model

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider