Key result
Intravenous amiodarone suppressed epinephrine-, digitalis-, and coronary ligation-induced arrhythmias in canine models, likely through class I, II, and IV actions rather than class III effects.
Why the study?
Does intravenously administered amiodarone suppress ventricular arrhythmias in canine models?
Does intravenously administered amiodarone suppress ventricular arrhythmias in canine models?
Intravenous amiodarone suppresses ventricular arrhythmias in canine models likely through class I, II, and IV actions rather than class III action, as it did not prolong the QTc interval.
No takes yet. Share an insight, caveat, or question.
Amiodarone suppresses select canine ventricular arrhythmias independently of plasma levels; leaves open human dosing mechanisms and applicability.
Awaji et al. (1995) studied Canine ventricular arrhythmia. Intravenously administered amiodarone was evaluated on Suppression of arrhythmia. Intravenous amiodarone suppressed epinephrine-, digitalis-, and coronary ligation-induced arrhythmias in canine models, likely through class I, II, and IV actions rather than class III effects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: