Key result
A prior oral loading of amiodarone significantly reduced the incidence of ventricular fibrillation during coronary ligation and reperfusion compared to control (25% vs 87.5%, P<0.05) without prolonging the QT interval.
Why the study?
Does prior oral loading of amiodarone prevent arrhythmias in a canine coronary ligation/reperfusion model?
Does prior oral loading of amiodarone prevent arrhythmias in a canine coronary ligation/reperfusion model?
Absolute Event Rate: 25% vs 87.5%
p-value: p=<0.05
In a canine model, prior oral loading of amiodarone suppressed ischemia/reperfusion-induced arrhythmias without prolonging the QT interval, distinguishing its effects from other class III antiarrhythmic drugs.
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Prior oral amiodarone loading fails to suppress canine reperfusion arrhythmias; leaves open human dosing or species translation.
Nagasawa et al. (2005) studied Coronary ligation/reperfusion-induced arrhythmia (n=16). Amiodarone vs. Empty gelatin capsules was evaluated on Incidence of ventricular fibrillation during coronary ligation and reperfusion (p=<0.05). A prior oral loading of amiodarone significantly reduced the incidence of ventricular fibrillation during coronary ligation and reperfusion compared to control (25% vs 87.5%, P<0.05) without prolonging the QT interval.
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