What is the clinical evidence from this study?

Population: Myocardial infarction. Intervention: Amiodarone. Primary outcome: Electrophysiological and antiarrhythmic effects.

What question did this study set out to answer?

This study aims to evaluate the electrophysiological and antiarrhythmic effects of amiodarone in dogs with myocardial infarcts.

December 1, 1990Journal of Cardiovascular Pharmacology

Effects of Amiodarone on Cardiac Electrophysiology and Inducibility of Arrhythmias in Chronically Infarcted Dogs: Late Arrhythmias, Haemodynamics, and Sympatholytic Actions

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Key result

Both acute intravenous and chronic oral amiodarone protected against inducible arrhythmias in dogs with myocardial infarction, with oral amiodarone also prolonging ventricular repolarization.

Why the study?

Does acute and chronic amiodarone alter cardiac electrophysiology and reduce inducibility of arrhythmias in dogs with recent myocardial infarction?

Key Points

This study aims to evaluate the electrophysiological and antiarrhythmic effects of amiodarone in dogs with myocardial infarcts.
Anaesthetised dogs with 5-6-day-old myocardial infarcts were treated with amiodarone both intravenously and orally.
The acute treatment involved doses of 2 and 10 mg/kg i.v., while the chronic treatment was 400 mg/day p.o. for 28 days.
Electrophysiological parameters were measured, including RR interval, PR interval, and conduction times.
Intravenous amiodarone prolonged RR interval, PR interval, and conduction times by 36%, 33%, and 25% respectively; oral amiodarone resulted in greater increases of 50%, 57%, and 12%.
Oral amiodarone significantly increased ventricular refractory periods and QRS duration (4%), QT interval (34%), and paced QT (19%).
Oral treatment reduced blood pressure by 13% and left ventricular dP/dt/P by 24%, while maintaining cardiac output through increased stroke volume.

Structured PICO

Does acute and chronic amiodarone alter cardiac electrophysiology and reduce inducibility of arrhythmias in dogs with recent myocardial infarction?

Population

Anaesthetised dogs with 5-6-day-old myocardial infarcts treated with acute or chronic amiodarone.

Intervention

Acute (2 and 10 mg/kg i.v.) and chronic (400 mg/day p.o. for 28 days) amiodarone

Outcome

Cardiac electrophysiology (RR interval, sinus node recovery time, PR interval, conduction times, refractory periods) and inducibility of arrhythmiassurrogate

In a canine model of recent myocardial infarction, both acute intravenous and chronic oral amiodarone demonstrated significant electrophysiological changes and protection against inducible arrhythmias.

Discussion

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Implication

Differential EP effects of acute IV vs chronic oral amiodarone seen in canine infarcts; leaves open translation to human post-MI arrhythmia management.

Cite This Study

Winslow et al. (1990) studied Myocardial infarction. Amiodarone was evaluated on Electrophysiological and antiarrhythmic effects. Both acute intravenous and chronic oral amiodarone protected against inducible arrhythmias in dogs with myocardial infarction, with oral amiodarone also prolonging ventricular repolarization.

synapsesocial.com/papers/6a6b752447a1bfb288f3226d https://doi.org/10.1097/00005344-199012000-00006

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Implication

Differential EP effects of acute IV vs chronic oral amiodarone seen in canine infarcts; leaves open translation to human post-MI arrhythmia management.

Effects of Amiodarone on Cardiac Electrophysiology and Inducibility of Arrhythmias in Chronically Infarcted Dogs: Late Arrhythmias, Haemodynamics, and Sympatholytic Actions

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Effects of Amiodarone on Cardiac Electrophysiology and Inducibility of Arrhythmias in Chronically Infarcted Dogs: Late Arrhythmias, Haemodynamics, and Sympatholytic Actions

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider