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November 1, 1997Journal of Cardiovascular Electrophysiology

Chronic Amiodarone Reduces Transmural Dispersion of Repolarization in the Canine Heart

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Why the study?

Does chronic amiodarone reduce transmural dispersion of repolarization in the canine left ventricle?

Population

Mongrel dogs (canine left ventricle tissues: epicardial, endocardial, mid-myocardial, and transmural strips)

Comparison

Amiodarone orally for 30 to 45 days vs Untreated controls

Design

Preclinical

Follow-up

30 to 45 days

Authors

SSSerge SicouriElectrophysiologySLSilvio LitovskyCross-Cutting CardiologyMEMarcelo V. ElizariElectrophysiology

Discussion

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Implication

May underlie amiodarone's favorable risk profile in canines; hypothesis-generating for human translation.

Structured PICO

Does chronic amiodarone reduce transmural dispersion of repolarization in the canine left ventricle?

P
Population
Mongrel dogs (canine left ventricle tissues: epicardial, endocardial, mid-myocardial, and transmural strips)
I
Intervention
Amiodarone orally (30 to 40 mg/kg per day) for 30 to 45 days
C
Comparator
Untreated controls
O
Outcome
Transmural dispersion of repolarization (action potential duration)surrogate

Chronic amiodarone reduces transmural dispersion of repolarization in the canine heart, providing a potential mechanism for its high antiarrhythmic efficacy and low proarrhythmic risk compared to other Class III agents.

Cite This Study

Sicouri et al. (1997) studied this question.

synapsesocial.com/papers/6a7e2168e99e489715ae8e03https://doi.org/10.1111/j.1540-8167.1997.tb01018.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparison of the Electrophysiologic Effects of Acute and Chronic Amiodarone Administration on Canine Purkinje Fibers1989 · 27 citations
  2. 2Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: evidence for calcium channel-blocking activity.1987 · 94 citations
  3. 3Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes1996 · 74 citations
  4. 4Frequency-dependent electrophysiologic effects of amiodarone in humans.1993 · 109 citations
  5. 5Frequency Dependent Effects of d‐Sotalol and Amiodarone on the Action Potential Duration of the Human Right Ventricle1992 · 34 citations