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May 1, 1989Journal of Cardiovascular Pharmacology

A Comparison of the Electrophysiologic Effects of Acute and Chronic Amiodarone Administration on Canine Purkinje Fibers

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Why the study?

Does acute versus chronic amiodarone administration have different electrophysiologic effects on canine Purkinje fibers?

Population

Canine Purkinje fibers from dogs treated chronically with amiodarone for 3 weeks and from untreated dogs

Comparison

Acute amiodarone superfusion (5 X 10 M for 1 h)… vs Fibers from untreated dogs superfused with blood…

Design

Preclinical

Follow-up

3 weeks (for chronic treatment)

Authors

JGJohn D. GallagherUniversity of LeedsJBJohn BianchiThe University of Texas Health Science Center at HoustonLGLawrence J. GessmanCooper Medical School of Rowan University

Discussion

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Implication

Acute-chronic amiodarone divergence in canine Purkinje fibers cautions against acute-only models; leaves open chronic dosing implications for arrhythmia research.

Structured PICO

Does acute versus chronic amiodarone administration have different electrophysiologic effects on canine Purkinje fibers?

P
Population
Canine Purkinje fibers from dogs treated chronically with amiodarone for 3 weeks and from untreated dogs
I
Intervention
Acute amiodarone superfusion (5 X 10(-5) M for 1 h) and chronic amiodarone administration (for 3 weeks)
C
Comparator
Fibers from untreated dogs superfused with blood from untreated dogs
O
Outcome
Action potential duration to 50% and 90% repolarization and Vmax of phase 0surrogate

Acute and chronic amiodarone administration exert differing electrophysiologic effects on canine Purkinje fibers, highlighting the importance of chronic dosing models for understanding its antiarrhythmic mechanisms.

Cite This Study

Gallagher et al. (1989) studied this question.

synapsesocial.com/papers/6a7163a0f44fa9f079df2fdbhttps://doi.org/10.1097/00005344-198905000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Electrophysiologic Effects of Chronically Administered Amiodarone on Canine Purkinje Fibers versus Ventricular Muscle1996 · 37 citations
  2. 2Chronic Amiodarone Reduces Transmural Dispersion of Repolarization in the Canine Heart1997 · 150 citations
  3. 3Potent Antiarrhythmic Effects of Chronic Amiodarone in Canine Pulmonary Vein Sleeve Preparations2009 · 23 citations
  4. 4Rate-related electrophysiologic effects of long-term administration of amiodarone on canine ventricular myocardium in vivo.1989 · 76 citations
  5. 5Effects of chronic treatment by amiodarone on transmural heterogeneity of canine ventricular repolarization in vivo: interactions with acute sotalol1999 · 51 citations