Key result
Chronic amiodarone preferentially suppressed arrhythmogenic substrates and triggers in canine pulmonary vein sleeves, increasing the basic cycle length for 1:1 activation failure from 124 to 420 ms (P<0.01).
Why the study?
Does chronic amiodarone alter the electrophysiological characteristics and suppress triggered activity in canine pulmonary vein sleeve preparations?
Population
Canine pulmonary vein (PV) sleeve preparations and left ventricular (LV) wedge preparations isolated from dogs
Comparison
Chronic amiodarone (40 mg/kg daily for 6 weeks) vs Untreated dogs
Design
Preclinical
Follow-up
6 weeks
Authors
Loading...
Hypothesis-generating for amiodarone's PV effects in AF models; leaves open translation to human therapy.
Does chronic amiodarone alter the electrophysiological characteristics and suppress triggered activity in canine pulmonary vein sleeve preparations?
Absolute Event Rate: 420% vs 124%
p-value: p=<0.01
Chronic amiodarone preferentially suppresses arrhythmogenic substrates and triggers in canine pulmonary vein sleeves, highlighting a potential mechanism for its efficacy in atrial fibrillation.
Sicouri et al. (2009) studied Arrhythmia. Amiodarone vs. Untreated was evaluated on Basic cycle length leading to 1:1 activation failure (ms) (p=<0.01). Chronic amiodarone preferentially suppressed arrhythmogenic substrates and triggers in canine pulmonary vein sleeves, increasing the basic cycle length for 1:1 activation failure from 124 to 420 ms (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: