Key result
Chronic amiodarone causes repolarization delay via decreased potassium current density, whereas acute amiodarone decreases action potential duration and inhibits maximum upstroke velocity.
Population
Mammalian hearts (papillary muscles or single ventricular cells isolated from rabbits, guinea pigs, or rats)
Comparison
Acute amiodarone or chronic oral amiodarone vs Control (untreated animals/cells)
Design
Review
Authors
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Distinguishes acute versus chronic amiodarone electrophysiology; extends mechanistic understanding but leaves open clinical translation.
The study elucidates the distinct acute and chronic electrophysiological mechanisms of amiodarone, highlighting that chronic use primarily delays repolarization via gene expression modulation of potassium channels.
Kodama et al. (1996) conducted a review in Mammalian ventricular cells. Amiodarone vs. Control was evaluated on Electrophysiological effects (action potential duration, Vmax, calcium and potassium currents). Chronic amiodarone causes repolarization delay via decreased potassium current density, whereas acute amiodarone decreases action potential duration and inhibits maximum upstroke velocity.
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