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March 1, 1996British Journal of PharmacologyOpen Access

Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes

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Why the study?

Does acute and chronic amiodarone treatment alter transmembrane ionic currents differently in rabbit ventricular myocytes?

Population

Rabbit single ventricular myocytes

Comparison

Acute exposure to amiodarone and chronic… vs Untreated/baseline state

Design

Preclinical

Follow-up

3-4 weeks (for chronic treatment)

Authors

AVAndrás VarróElectrophysiologyLVLászló VirágUniversity of SzegedJPJulius Gy. PappElectrophysiology

Discussion

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Implication

Differential acute-chronic amiodarone effects on rabbit myocyte currents remain hypothesis-generating; leaves open translation to human electrophysiology.

Structured PICO

Does acute and chronic amiodarone treatment alter transmembrane ionic currents differently in rabbit ventricular myocytes?

P
Population
Rabbit single ventricular myocytes
I
Intervention
Acute exposure to amiodarone (1 and 5 microM) and chronic amiodarone treatment (i.p. 50 mg/kg/day for 3-4 weeks)
C
Comparator
Untreated/baseline state
O
Outcome
Amplitude and kinetics of transmembrane ionic currents (inward calcium current, delayed rectifier outward potassium current, transient outward current, inward rectifier potassium current)surrogate

Acute and chronic amiodarone treatments alter transmembrane ionic currents differently in ventricular myocytes, potentially explaining differences in clinical electrophysiological effects.

Cite This Study

Varró et al. (1996) studied this question.

synapsesocial.com/papers/6a7163a0f44fa9f079df2fd8https://doi.org/10.1111/j.1476-5381.1996.tb16713.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of long‐term oral administration of amiodarone on the electromechanical performance of rabbit ventricular muscle1992 · 37 citations
  2. 2A Comparison of the Electrophysiologic Effects of Acute and Chronic Amiodarone Administration on Canine Purkinje Fibers1989 · 27 citations
  3. 3The effect of amiodarone, a new anti‐anginal drug, on cardiac muscle1970 · 554 citations
  4. 4Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: evidence for calcium channel-blocking activity.1987 · 94 citations
  5. 5Voltage- and Use-Dependent Modulation of Calcium Channel Current in Guinea Pig Ventricular Cells by Amiodarone and Des-Oxo-Amiodarone1991 · 23 citations