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October 1, 1992British Journal of PharmacologyOpen Access

Effects of long‐term oral administration of amiodarone on the electromechanical performance of rabbit ventricular muscle

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Why the study?

Does long-term oral amiodarone alter the electromechanical performance of rabbit ventricular muscle?

Population

Rabbits (ventricular muscle/papillary muscles)

Comparison

Oral amiodarone 50 mg or 100 mg kg-1 daily for 4… vs Controls

Design

Preclinical

Follow-up

4 weeks

Authors

IKItsuo KodamaTokyo Institute of TechnologyRSRyoko SuzukiUniversity of TsukubaKKKaichiro KamiyaNagoya University

Discussion

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Implication

Should not guide amiodarone use in patients; hypothesis-generating for chronic Class-III effects on ventricular performance.

Structured PICO

Does long-term oral amiodarone alter the electromechanical performance of rabbit ventricular muscle?

P
Population
Rabbits (ventricular muscle/papillary muscles)
I
Intervention
Oral amiodarone 50 mg or 100 mg kg-1 daily for 4 weeks
C
Comparator
Controls
O
Outcome
Transmembrane action potential and contraction of ventricular muscle (ECG parameters, APD, Vmax)surrogate

Chronic oral amiodarone in rabbits causes repolarization delay (Class-III action) with minimal frequency-dependence, while acute application adds a fast kinetic Class-I action.

Cite This Study

Kodama et al. (1992) studied this question.

synapsesocial.com/papers/6a73b1d6d3d4e530dbfb792fhttps://doi.org/10.1111/j.1476-5381.1992.tb12774.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Long-term Oral Administration of Amiodarone on the Ventricular Repolarization of Rabbit Hearts1996 · 21 citations
  2. 2Acute and Chronic Effects of Amiodarone on Mammalian Ventricular Cells.1996 · 29 citations
  3. 3Differential Electrophysiologic Effects of Chronically Administered Amiodarone on Canine Purkinje Fibers versus Ventricular Muscle1996 · 37 citations
  4. 4Rate-related electrophysiologic effects of long-term administration of amiodarone on canine ventricular myocardium in vivo.1989 · 76 citations
  5. 5Short- and Long-Term Effects of Amiodarone on the Two Components of Cardiac Delayed Rectifier K+Current2001 · 118 citations