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August 1, 1970British Journal of PharmacologyOpen Access

The effect of amiodarone, a new anti‐anginal drug, on cardiac muscle

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Why the study?

Does amiodarone alter cardiac action potentials and protect against ventricular fibrillation in animal models?

Population

Anaesthetized guinea-pigs and isolated rabbit atrial or ventricular muscle fibres

Comparison

Amiodarone vs Potassium iodide or simultaneous administration…

Design

Preclinical

Follow-up

6 weeks

Authors

BSBramah N. SinghElectrophysiologyEWE. M. Vaughan WilliamsHaffkine Institute

Discussion

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Implication

Animal data suggest amiodarone's antiarrhythmic potential; leaves open translation to human therapy.

Structured PICO

Does amiodarone alter cardiac action potentials and protect against ventricular fibrillation in animal models?

P
Population
Anaesthetized guinea-pigs and isolated rabbit atrial or ventricular muscle fibres
I
Intervention
Amiodarone (5% solution locally; 20 mg/kg daily for 6 weeks intraperitoneally)
C
Comparator
Potassium iodide (10 mg/kg daily for 6 weeks intraperitoneally) or simultaneous administration of thyroxine (5 mug daily for 3 weeks)
O
Outcome
Cardiac action potential duration and protection against ouabain-induced ventricular fibrillationsurrogate

Amiodarone prolongs cardiac action potentials similarly to thyroidectomy and protects against ouabain-induced ventricular fibrillation in animal models.

Cite This Study

Singh et al. (1970) studied this question.

synapsesocial.com/papers/6a127daaea48cb855a34f3dbhttps://doi.org/10.1111/j.1476-5381.1970.tb09891.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comparison of the anti‐arrhythmic actions of I.C.I. 50172 and (—)‐propranolol and their effects on intracellular cardiac action potentials and other features of cardiac function1969 · 79 citations
  2. 2The effect of altered thyroid state on atrial intracellular potentials1970 · 214 citations
  3. 3The relevance of β‐receptor blockade to ouabain‐induced cardiac arrhythmias1969 · 95 citations
  4. 4The effect of bretylium on intracellular cardiac action potentials in relation to its anti‐arrhythmic and local anaesthetic activity1969 · 50 citations