Why the study?
Does amiodarone alter circulating concentrations of thyroid hormones in patients treated for arrhythmias?
Population
Patients receiving amiodarone treatment for arrhythmias
Design
Review
Follow-up
greater than six months
Authors
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May warrant thyroid monitoring with long-term amiodarone; confirms alterations but leaves open outcome relevance.
Does amiodarone alter circulating concentrations of thyroid hormones in patients treated for arrhythmias?
Amiodarone treatment causes significant alterations in thyroid hormone profiles, including increased T4 and rT3 and decreased T3, which occur in both healthy subjects and those with structural heart disease.
Gammage et al. (1987) studied this question.
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