Why the study?
Does amiodarone alter thyroid function or cause hypothyroidism in patients with ischaemic heart disease?
Population
12 patients with ischaemic heart disease
Design
Case_series
Follow-up
Up to 6 weeks of treatment, plus 4 weeks after cessation
Authors
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Supports short-term amiodarone safety on thyroid function in IHD; leaves open longer-term effects and antianginal mechanisms.
Does amiodarone alter thyroid function or cause hypothyroidism in patients with ischaemic heart disease?
Short-term amiodarone therapy does not cause clinically significant hypothyroidism in patients with ischemic heart disease, suggesting its antianginal effects are not mediated by generalized hypothyroidism.
Pritchard et al. (1975) studied this question.
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