Why the study?
Does amiodarone alter serum thyroid hormones and hepatic thyroxine 5'-monodeiodination in male Fisher rats?
Does amiodarone alter serum thyroid hormones and hepatic thyroxine 5'-monodeiodination in male Fisher rats?
Amiodarone reduces peripheral conversion of T4 to T3 and lowers heart rate and cardiac Ca++ myosin ATPase activity in rats, suggesting it blocks some effects of thyroid hormone on the heart.
Rat data link amiodarone to reduced T3 conversion and cardiac ATPase; clinical implications require human confirmation.
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SOGOL et al. (1983) studied this question.
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