What question did this study set out to answer?

Summarize the pathophysiology, clinical alterations in thyroid hormone metabolism, and therapeutic strategies for amiodarone-induced thyroid dysfunction.

April 1, 2001Endocrine ReviewsOpen Access

The Effects of Amiodarone on the Thyroid*

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Authors

EMEnio MartinoUniversity of Pisa LBLuigi BartalenaUniversity of Pisa FBFausto BogazziUniversity of Pisa

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Clinical review demonstrates overt thyroid dysfunction in 14% to 18% of patients treated with amiodarone, highlighting distinct therapeutic approaches for drug-induced hypothyroidism and...

Key Points

Summarize the pathophysiology, clinical alterations in thyroid hormone metabolism, and therapeutic strategies for amiodarone-induced thyroid dysfunction.
Synthesized clinical and pharmacological evidence regarding alterations in thyroid function tests and hormone metabolism associated with amiodarone therapy.
Evaluated diagnostic criteria, underlying pathophysiological mechanisms, and medical management options for amiodarone-induced hypothyroidism and thyrotoxicosis.
Amiodarone inhibits 5'-deiodinase activity, leading to increased serum T4 and rT3 alongside decreased T3 concentrations, with overt thyroid dysfunction occurring in 14% to 18% of treated individuals.
Amiodarone-induced hypothyroidism results from a failure to escape the acute Wolff-Chaikoff effect, with preexisting Hashimoto's thyroiditis identified as a major predisposing risk factor.
Type I thyrotoxicosis is treated with thionamides and potassium perchlorate, whereas type II destructive thyroiditis responds most effectively to glucocorticoids.

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Martino et al. (2001) studied this question.

synapsesocial.com/papers/6a127da7ea48cb855a34f3b1 https://doi.org/10.1210/edrv.22.2.0427

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Implication

Clinical review demonstrates overt thyroid dysfunction in 14% to 18% of patients treated with amiodarone, highlighting distinct therapeutic approaches for drug-induced hypothyroidism and...

The Effects of Amiodarone on the Thyroid*

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Implication

Key Points

Cite This Study

The Effects of Amiodarone on the Thyroid*

Discussion

Member takes

Implication

Key Points

Cite This Study

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