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November 1, 1999Cardiovascular ResearchOpen Access

Effects of chronic treatment by amiodarone on transmural heterogeneity of canine ventricular repolarization in vivo: interactions with acute sotalol

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Why the study?

Does chronic amiodarone treatment affect transmural heterogeneity of ventricular repolarization and interact with acute sotalol in dogs?

Population

23 dogs (Group I n=8, Group II n=7, Group III n=8)

Comparison

Amiodarone 100 mg or 200 mg orally twice a day… vs No treatment (Group I)

Design

Preclinical

Follow-up

6 weeks to 8 months

Authors

JMJean MérotElectrophysiology

Discussion

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Implication

Animal data on amiodarone-sotalol interaction are hypothesis-generating; leaves open clinical translation to arrhythmia management.

Key Points

  • The study aims to explore how chronic amiodarone affects different ventricular cell types and interacts with sotalol.
  • Three groups of dogs were treated with different doses of amiodarone or no treatment for 6 weeks to 8 months.
  • In vivo studies resulted in electrophysiologic recordings under anesthesia following treatment.
  • Cellular properties of right ventricular tissues were assessed through cardiac biopsies.
  • Chronic amiodarone decreased plasma triiodothyronine levels (P < 0.001) and increased QT interval by 14% in high-dose group (P < 0.05).
  • Amiodarone prevented sotalol-induced increases in transmural repolarization dispersion (34 +/- 8 ms in group III, P < 0.05).
  • Amiodarone also inhibited sotalol-induced ventricular tachyarrhythmias and prolonged MAP duration.

Structured PICO

Does chronic amiodarone treatment affect transmural heterogeneity of ventricular repolarization and interact with acute sotalol in dogs?

P
Population
23 dogs (Group I n=8, Group II n=7, Group III n=8)
I
Intervention
Amiodarone 100 mg or 200 mg orally twice a day for 6 weeks to 8 months, followed by acute sotalol
C
Comparator
No treatment (Group I)
O
Outcome
Transmural heterogeneity of ventricular repolarization and interactions with acute sotalolsurrogate

Chronic amiodarone treatment in dogs prolongs repolarization without increasing transmural dispersion and protects against sotalol-induced repolarization dispersion and arrhythmias.

Cite This Study

Jean Mérot (1999) studied this question.

synapsesocial.com/papers/6a0883c37de338f10b10bee1https://doi.org/10.1016/s0008-6363(99)00232-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Electrophysiologic Effects of Chronically Administered Amiodarone on Canine Purkinje Fibers versus Ventricular Muscle1996 · 37 citations
  2. 2Combination of Sotalol and Quinidine in a Canine Model of Torsades de Pointes1998 · 13 citations
  3. 3A comparison of the electrophysiologic effects of intravenous and oral amiodarone in the same patient.1984 · 140 citations
  4. 4Amiodarone versus amiodarone and a type IA agent for treatment of patients with rapid ventricular tachycardia.1986 · 19 citations
  5. 5Sodium Channel Block With Mexiletine Is Effective in Reducing Dispersion of Repolarization and Preventing Torsade de Pointes in LQT2 and LQT3 Models of the Long-QT Syndrome1997 · 529 citations