What question did this study set out to answer?

To establish the effects of oral loading and maintenance doses of amiodarone on cardiac function, electrocardiography, exercise tolerance, and serum biochemistry in healthy dogs.

May 1, 2002Journal of Veterinary Internal MedicineOpen Access

Effects of Chronic Oral Amiodarone on Left Ventricular Function, ECGs, Serum Chemistries, and Exercise Tolerance in Healthy Dogs

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Why the study?

Does chronic oral amiodarone affect left ventricular function, ECGs, serum chemistries, and exercise tolerance in healthy dogs?

Key Points

To establish the effects of oral loading and maintenance doses of amiodarone on cardiac function, electrocardiography, exercise tolerance, and serum biochemistry in healthy dogs.
Administered oral amiodarone at a loading dose of 25 mg/kg every 12 hours for 3.5 weeks, followed by a maintenance dose of 30 mg/kg every 24 hours for 3.5 weeks in adult, clinically normal dogs.
Measured systemic arterial pressure, echocardiographic left ventricular parameters, ECG intervals, exercise tolerance, and serum chemistries, analyzing data with repeated-measures ANOVA and Bonferroni's post hoc tests.
The loading dose induced significant decreases in body weight and heart rate alongside significant increases in PQ, QT, and corrected QT (QTc) intervals (P < .05), all of which returned to pretest baseline levels during the maintenance phase.
Serum hepatic enzyme activities and cholesterol concentrations increased, whereas thyroid hormones (T3 and T4), phosphorus, and total carbon dioxide concentrations decreased.
Appetite suppression occurred exclusively at the 25 mg/kg twice-daily loading dose, while the 30 mg/kg daily maintenance dose produced no toxicologically significant ECG or echocardiographic alterations.

Structured PICO

Does chronic oral amiodarone affect left ventricular function, ECGs, serum chemistries, and exercise tolerance in healthy dogs?

Population

Adult, clinically normal dogs

Intervention

Amiodarone 25 mg/kg q12h loading dose and 30 mg/kg q24h maintenance dose, each given PO for 3.5 weeks

Comparator

Pretest values (baseline)

Outcome

Systemic arterial pressure, echocardiographic (ECHO) indices of left ventricular function, ECGs, exercise tolerance, and serum biochemistriessurrogate

In healthy dogs, a loading dose of amiodarone causes transient ECG changes and appetite suppression, while a maintenance dose of 30 mg/kg q24h produces no clinically significant ECG or ECHO changes.

Discussion

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Implication

Supports ECG monitoring during amiodarone loading in dogs; leaves open effects in clinical cardiac disease.

Cite This Study

Bicer et al. (2002) studied this question.

synapsesocial.com/papers/6a712b2345e51b8c20274c8d https://doi.org/10.1111/j.1939-1676.2002.tb02365.x

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Effects of Chronic Oral Amiodarone on Left Ventricular Function, ECGs, Serum Chemistries, and Exercise Tolerance in Healthy Dogs

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Effects of Chronic Oral Amiodarone on Left Ventricular Function, ECGs, Serum Chemistries, and Exercise Tolerance in Healthy Dogs

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider