What question did this study set out to answer?

To evaluate the clinical efficacy, dosage regimens, and adverse effect profile of oral amiodarone in client-owned dogs diagnosed with atrial fibrillation.

July 1, 2006Journal of Veterinary Internal Medicine

Oral Amiodarone Therapy in Dogs with Atrial Fibrillation

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Why the study?

Does oral amiodarone reduce heart rate and restore sinus rhythm in dogs with atrial fibrillation?

Key Points

To evaluate the clinical efficacy, dosage regimens, and adverse effect profile of oral amiodarone in client-owned dogs diagnosed with atrial fibrillation.
Retrospective medical record review of client-owned dogs (N=17) treated with oral amiodarone for atrial fibrillation secondary to underlying cardiac diseases including cardiomyopathy and valvular endocardiosis.
Evaluated loading doses (median 16.5 mg/kg/day) and maintenance doses (median 9.0 mg/kg/day), along with clinical outcomes, serial examinations, and biochemical monitoring.
A greater than 20% reduction in heart rate was achieved in 76% of dogs (13/17), and conversion to sustained sinus rhythm occurred in 35% of dogs (6/17).
Therapy was discontinued in 5 dogs, with dosage adjustments or cessations driven by symptomatic bradycardia (n=1), asymptomatic hepatic enzyme elevation (n=1), and symptomatic hepatic enzyme elevation (n=3).

Structured PICO

Does oral amiodarone reduce heart rate and restore sinus rhythm in dogs with atrial fibrillation?

Population

17 client-owned dogs with atrial fibrillation and various underlying cardiac diseases (cardiomyopathy, valvular endocardiosis, and congenital heart disease).

Intervention

Oral amiodarone (median loading dose 16.5 mg/kg/d, median maintenance dose 9.0 mg/kg/d).

Outcome

Decrease in heart rate (>20%) and conversion to sinus rhythm.surrogate

Oral amiodarone is effective for rate control and rhythm conversion in dogs with atrial fibrillation, though hepatic and bradycardic adverse effects require monitoring.

Discussion

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Implication

May support rate control with oral amiodarone in canine AF; leaves open need for prospective trials on safety and rhythm conversion.

Cite This Study

Saunders et al. (2006) studied this question.

synapsesocial.com/papers/6a79bce01ba4614d7ff3a45b https://doi.org/10.1111/j.1939-1676.2006.tb01806.x

View Full Paper

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Oral Amiodarone Therapy in Dogs with Atrial Fibrillation

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Oral Amiodarone Therapy in Dogs with Atrial Fibrillation

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider