Key result
Acute amiodarone modifies both active and passive membrane properties, whereas chronic amiodarone alters only active properties, likely mediated by desethylamiodarone.
Acute amiodarone modifies both active and passive membrane properties, whereas chronic amiodarone alters only active properties, suggesting desethylamiodarone plays an important role in chronic treatment.
No takes yet. Share an insight, caveat, or question.
Highlights distinct acute versus chronic amiodarone membrane effects in animals; leaves open clinical translation and desethylamiodarone role in patients.
Quinteiro et al. (1994) studied this question. Chronic vs acute amiodarone and desethylamiodarone vs. Control was evaluated on Relationship between changes in maximum rate of depolarization (Vmax) and conduction velocity (theta), and space constant. Acute amiodarone modifies both active and passive membrane properties, whereas chronic amiodarone alters only active properties, likely mediated by desethylamiodarone.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: