Key result
Both acute and chronic amiodarone improve post-ligation survival in rats, but only chronic reduces VF.
Why the study?
The comparative antiarrhythmic effects of acute versus chronic amiodarone pretreatment in the early phase of arrhythmias induced by coronary artery ligation were unclear.
Does amiodarone pretreatment improve survival and reduce ventricular fibrillation in conscious rats with coronary artery ligation?
Does amiodarone pretreatment improve survival and reduce ventricular fibrillation in conscious rats with coronary artery ligation?
In a rat model of coronary ligation, chronic amiodarone pretreatment was more effective than acute pretreatment at reducing ventricular fibrillation.
The effect of amiodarone after acute and chronic pretreatment was studied in the early phase of arrhythmias induced by coronary artery ligation in conscious rats. Both acute and chronic amiodarone pretreatments improved survival during the first 20 min after coronary ligation. Only chronic amiodarone pretreatment reduced significantly the incidence of ventricular fibrillation. It was concluded that chronic amiodarone pretreatment seemed to be more effective than the acute one.
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Varró et al. (1986) studied Arrhythmias induced by coronary artery ligation. Amiodarone (acute and chronic pretreatment) was evaluated on Survival and incidence of ventricular fibrillation. Both acute and chronic amiodarone pretreatments improved survival after coronary ligation in conscious rats, but only chronic pretreatment significantly reduced ventricular fibrillation.
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