Why the study?
Do amiodarone and dronedarone improve action potential characteristics and reduce arrhythmia in isolated rat hearts during reperfusion after low-flow ischemia?
Do amiodarone and dronedarone improve action potential characteristics and reduce arrhythmia in isolated rat hearts during reperfusion after low-flow ischemia?
Amiodarone and dronedarone exhibit anti-ischemic actions and suppress reperfusion-induced ventricular tachycardia in isolated rat hearts via a class III-independent mechanism.
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Hypothesis-generating for class III-independent effects in reperfusion; should not yet change clinical practice.
Rochetaing et al. (2001) studied this question.
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