What question did this study set out to answer?

To investigate whether acute administration of amiodarone potentiates the cardiotoxic effects of doxorubicin during ischemia and reperfusion.

August 1, 1990Cardiovascular Research

Antiarrhythmic effect of amiodarone on doxorubicin acute toxicity in working rat hearts

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Why the study?

Does amiodarone potentiate the cardiotoxicity of doxorubicin in working rat hearts?

Population

32 adult male Sprague-Dawley rats (250-300 g)

Comparison

Amiodarone 50 mg/kg/day for 5 days followed by… vs Control, amiodarone alone, and doxorubicin alone

Design

Preclinical

Follow-up

60 minutes

Authors

CLC. LambertUniversité de Lorraine CMClaude MossiatInserm MTMarianne Tannière‐ZellerUniversité de Bourgogne

Discussion

Member takes

Implication

Supports combined testing in rat models without added acute toxicity; leaves open clinical translation.

Key Points

To investigate whether acute administration of amiodarone potentiates the cardiotoxic effects of doxorubicin during ischemia and reperfusion.
Perfusion studies were conducted on isolated working hearts from 32 adult male Sprague-Dawley rats pretreated with or without amiodarone (50 mg/kg/day for 5 days).
Hearts were perfused with or without doxorubicin (6 mg/L) for 40 minutes, followed by 10 minutes of left main coronary artery ligation and 10 minutes of reperfusion.
Cardiac output, heart rate, and ECG-measured mean duration of reperfusion-induced ventricular fibrillation were evaluated across four experimental groups.
After 40 minutes of perfusion, cardiac output was stable in control and amiodarone-alone hearts, but decreased by 25.5% in the doxorubicin group and 30.4% in the amiodarone-doxorubicin group.
Mean reperfusion fibrillation durations were 331 (73) seconds in controls and 444 (86) seconds with doxorubicin alone, compared to 66 (22) seconds with amiodarone alone and 22 (9) seconds with amiodarone plus doxorubicin.

Structured PICO

Does amiodarone potentiate the cardiotoxicity of doxorubicin in working rat hearts?

Population

32 adult male Sprague-Dawley rats (250-300 g)

Intervention

Amiodarone 50 mg/kg/day for 5 days followed by perfusion with doxorubicin 6 mg/L

Comparator

Control (no pretreatment, no doxorubicin), amiodarone alone, and doxorubicin alone

Outcome

Cardiac output, heart rate, and mean fibrillation duration induced by reperfusionsurrogate

Amiodarone does not potentiate the acute cardiotoxicity of doxorubicin while maintaining its antiarrhythmic efficacy in a rat heart model.

Cite This Study

Lambert et al. (1990) studied this question.

synapsesocial.com/papers/6a6f24f9439bab0cabc2b2ed https://doi.org/10.1093/cvr/24.8.653

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Antiarrhythmic effect of amiodarone on doxorubicin acute toxicity in working rat hearts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Antiarrhythmic effect of amiodarone on doxorubicin acute toxicity in working rat hearts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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