What does this research mean for the field?

Phentolamine effectively prevents reperfusion-induced ventricular arrhythmias, likely by decreasing the dispersion of refractoriness between normal and ischemic zones and preventing the rapid increase in refractory period after reperfusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1980Journal of Cardiovascular Pharmacology

Electrophysiologic and Antiarrhythmic Effects of Phentolamine in Experimental Coronary Artery Occlusion and Reperfusion in the Dog

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Why the study?

Does phentolamine reduce ventricular arrhythmias in a canine model of acute coronary artery occlusion and reperfusion?

Population

Anesthetized dogs undergoing acute coronary artery occlusion and reperfusion

Comparison

Phentolamine 0.25 mg/kg bolus 30 min before… vs Saline

Design

Preclinical

Follow-up

1 hour occlusion followed by up to 4 hours reperfusion

Authors

JSJames R. StewartIndiana University WBWilliam E. BurmeisterEuropean Molecular Biology Laboratory JBJennifer BurmeisterUniversity of Michigan

Discussion

Member takes

Implication

Phentolamine may attenuate reperfusion arrhythmias in canines; leaves open translation to human acute coronary syndromes.

Structured PICO

Does phentolamine reduce ventricular arrhythmias in a canine model of acute coronary artery occlusion and reperfusion?

Population

Anesthetized dogs undergoing acute coronary artery occlusion (proximal left circumflex or left anterior descending diagonal branches) and reperfusion

Intervention

Phentolamine 0.25 mg/kg bolus 30 min before occlusion, followed by continuous intravenous infusion of 0.15 mg/kg/min

Comparator

Saline

Outcome

Number of premature ventricular contractions (PVCs) and complexity of ventricular ectopy during reperfusionsurrogate

Phentolamine prevents reperfusion ventricular arrhythmias in a canine model, potentially by modulating refractoriness between normal and ischemic zones.

Cite This Study

Stewart et al. (1980) studied this question.

synapsesocial.com/papers/6a15378d79ff98d0de4e44dd https://doi.org/10.1097/00005344-198001000-00009

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Electrophysiologic and Antiarrhythmic Effects of Phentolamine in Experimental Coronary Artery Occlusion and Reperfusion in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiologic and Antiarrhythmic Effects of Phentolamine in Experimental Coronary Artery Occlusion and Reperfusion in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider