Key result
Infusions of phentolamine in anaesthetized dogs increased heart rate, peak tension, coronary blood flow, and myocardial oxygen consumption, accompanied by raised noradrenaline levels.
Why the study?
Does phentolamine infusion alter myocardial function and noradrenaline levels in anaesthetized dogs?
Population
Anaesthetized dogs on right-sided cardiac bypass, perfused under conditions of constant flow
Design
Preclinical
Authors
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Phentolamine may reduce cardiac efficiency in dogs via noradrenaline release; leaves open translation to human myocardial function.
Does phentolamine infusion alter myocardial function and noradrenaline levels in anaesthetized dogs?
In a canine model, phentolamine infusion alters myocardial function and increases coronary venous noradrenaline levels, reducing cardiac efficiency at higher doses.
Nayler et al. (1972) studied this question. Phentolamine was evaluated on Myocardial function and noradrenaline levels. Infusions of phentolamine in anaesthetized dogs increased heart rate, peak tension, coronary blood flow, and myocardial oxygen consumption, accompanied by raised noradrenaline levels.
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